Design and synthesis of ONOO − activatable molecular probe with NIR-II

Download scientific diagram | Design and synthesis of ONOO − activatable molecular probe with NIR-II fluorescence. Conditions: (a) Et 2 NH, Pd 2 (dba) 3 , DavePhos, Cs 2 CO 3 , dioxene, 95 °C, 18 h; (b) i CH 3 MgBr, ii HClO 4 ; (c) toluene/n-butanol, 100 °C, 12 h. from publication: Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring | Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO-) is proposed as an early sign in the progression of drug-induced hepatotoxicity. Currently, reported ONOO- probes mainly emit in visible range | Hepatotoxicity, Fluorescence and Drug-Induced Liver Injury | ResearchGate, the professional network for scientists.

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