Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity.
![Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity.](https://www.researchgate.net/publication/6456924/figure/fig7/AS:339894355415061@1458048537619/Proposed-mechanism-for-the-roles-of-ONOO-and-U-NO-on-PGHS-1-activity.png)
Download scientific diagram | Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity. Peroxynitrite-derived radicals inactivate PGHS-1. In parallel, U NO 2 causes both from publication: Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation | Peroxynitrite (ONOO(-)) can serve either as a peroxide substrate or as an inactivator of prostaglandin endoperoxide H synthase-1 (PGHS-1). Herein, the mechanism of PGHS-1 inactivation by ONOO(-) and the modulatory role that nitric oxide (*NO) plays in this process were | Free Radicals, Nitric Oxide and Prostaglandin-Endoperoxide Synthases | ResearchGate, the professional network for scientists.
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Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity.
![](https://www.ahajournals.org/cms/asset/f74c0f7a-8c57-486f-bfed-306b43c0280a/5ff2.jpeg)
Cardiovascular Consequences When Nitric Oxide and Lipid Signaling Converge